Tissue-specific gene expression in obese hyperglycemic mice

Tissue Specific Expression of Human Calcitonin Gene in Potato Tubers by an Organ Specific Promoter

To increase the production level of heterologous proteins in plants, strategies such as choice of strongerpromoters, optimization of codon usage and specific localization of foreign proteins are of major concern.Calcitonin (CT), a 32 amino acid polypeptide is a powerful and specific inhibitor of bone resorption and isused to treat several human diseases. Calcitonin activity is...

Hereditary Obese-Hyperglycemic Syndrome of Mice *

The metabolic characteristics of a new Mendelian recessive syndrome in mice have been described in previous publications. The condition is characterized by an adult body weight of 50-100 g. instead of a normal 20-30 g., sterility,'0 hyperglycemia and glycosuria,'7 atrophic changes and ulceration of the skin, and decreased life span. Histopathological studies reveal enlarged islets of Langerhans...

Metabolism in Vitro of Adipose Tissue in Obese-hyperglycemic

Although obesity implies excessive storage of fat in adipose tissue, the possibility that a metabolic anomaly of this tissue might underlie at least certain forms of obesity has received relatively little attention. Recent emphasis in several laboratories upon the importance of adipose tissue as a site of metabolic homeostasis for carbohydrates and fats clearly suggests that a re-evaluation of ...

Hyperglycemic Challenge and Distribution of Adipose Tissue in Obese Baboons

BACKGROUND Blood glucose levels regulate the rate of insulin secretion, which is the body's mechanism for preventing excessive elevation in blood glucose. Impaired glucose metabolism and insulin resistance have been linked to excess body fat composition. Here, we quantify abdominal muscle and abdominal adipose tissue compartments in a large nonhuman primate, the baboon, and investigate their re...

Imperfect homeothermia in the hereditary obese-hyperglycemic syndrome of mice.